LHRH THERAPY IN TEN MALE AND TEN FEMALE PATIENTS

We treated ten men and ten women suffering from hypogonadotropic hypogonadism with LHRH. Our method of treatment differed 'from others in that a mini pump was not available at the onset of the study. Nine women were given injections via a heparinized indwelling catheter every 120 minutes for 14 days, i,e. the proliferative phase. After ovulation, 3000 IU human chorionic gonadotropin (HCG) was administered every two days. A minipump was used for only one patient. From among these nine female patients, three pregnancies occurred, In male subjects, 50-100 micrograms LHRH was subcutaneously self-administered twice daily, and 5000 IU HCG was given intramuscularly twice weekly. With this treatment, secondary sexual characteristics appeared after a few months, including nocturnal ejaculation, growth of testes, and elevation of serum testosterone levels.